Immune System and Disorders Summary Your immune system is a complex network of cells, tissues, and organs that work together to defend against germs. It helps your body to recognize these “foreign” invaders. Then its job is to keep them out, or if it can’t, to find and destroy them. If your immune system cannot do its job, the results can be serious. Disorders of the immune system include Allergy and asthma – immune responses to substances that are usually not harmful Immune deficiency diseases – disorders in which the immune system is missing one or more of its parts Autoimmune diseases – diseases causing your immune system to attack your own body’s cells and tissues by mistake NIH: National Institute of Allergy and Infectious Diseases National Institute of Allergy and Infectious Diseases Array Agammaglobulinemia Aging changes in immunity Chronic granulomatous disease Graft-versus-host disease Histiocytosis Hyperimmunoglobulin E syndrome Immune response Immune response Immune System (For Parents) Nemours Foundation Immunodeficiency disorders Phagocytosis Selective deficiency of IgA Find an Expert American Academy of Allergy, Asthma, and Immunology American Academy of Allergy, Asthma, and Immunology Immune Deficiency Foundation Immune Deficiency Foundation National Institute of Allergy and Infectious Diseases National Institute of Allergy and Infectious Diseases Encyclopedia Antibody titer Chediak-Higashi syndrome Exercise and immunity Immunoelectrophoresis – blood Immunofixation – blood Latex agglutination test Nitroblue tetrazolium test Quantitative nephelometry Serum sickness Related Issues Autoinflammatory Diseases National Institute of Arthritis and Musculoskeletal and Skin Diseases Flu Vaccine Guidance for Patients with Immune Deficiency American Academy of Allergy, Asthma, and Immunology IgG Replacement Therapy: When You Need It — and When You Don’t ABIM Foundation Primary Immune Deficiency Diseases: Talking to Your Doctor National Institute of Allergy and Infectious Diseases Recurrent Infections May Signal Immunodeficiencies American Academy of Allergy, Asthma, and Immunology Travelers’ Health: Immunocompromised Travelers Centers for Disease Control and Prevention Specifics Chronic Granulomatous Disease (CGD) National Institute of Allergy and Infectious Diseases Common Variable Immunodeficiency (CVID) National Institute of Allergy and Infectious Diseases Congenital Neutropenia Syndromes National Institute of Allergy and Infectious Diseases DiGeorge Syndrome (DGS) American Academy of Allergy, Asthma, and Immunology DOCK8 Deficiency National Institute of Allergy and Infectious Diseases General Information about Langerhans Cell Histiocytosis (LCH) National Cancer Institute Glycosylation Disorders with Immunodeficiency National Institute of Allergy and Infectious Diseases GVHD (Graft-Versus-Host Disease): A Guide for Patients and Families After Stem Cell Transplant National Institutes of Health, Clinical Center Hyper-IgM Syndrome National Institute of Allergy and Infectious Diseases Hyper-Immunoglobulin E Syndrome (HIES) or Job’s Syndrome National Institute of Allergy and Infectious Diseases Leukocyte Adhesion Deficiency (LAD) National Institute of Allergy and Infectious Diseases Mastocytosis National Institute of Allergy and Infectious Diseases Monoclonal Gammopathy of Undetermined Significance (MGUS) Mayo Foundation for Medical Education and Research NF-κB Essential Modifier (NEMO) Mutations National Institute of Allergy and Infectious Diseases PI3 Kinase Disease National Institute of Allergy and Infectious Diseases PLCG2-associatiated antibody deficiency immune dysregulation (PLAID) National Institute of Allergy and Infectious Diseases Selective IgA Deficiency American Academy of Allergy, Asthma, and Immunology Severe Combined Immunodeficiency (SCID) National Institute of Allergy and Infectious Diseases T Cells National Multiple Sclerosis Society Warts, Hypogammaglobulinemia, Infections, and Myelokathexis Syndrome (WHIMS) National Institute of Allergy and Infectious Diseases Wiskott-Aldrich Syndrome National Marrow Donor Program Wiskott-Aldrich Syndrome (WAS) National Institute of Allergy and Infectious Diseases X-Linked Agammaglobulinemia (XLA) National Institute of Allergy and Infectious Diseases X-Linked Lymphoproliferative Disease (XLP) National Institute of Allergy and Infectious Diseases Clinical Trials ClinicalTrials.gov: Granulomatous Disease, Chronic National Institutes of Health ClinicalTrials.gov: Immune System Diseases National Institutes of Health ClinicalTrials.gov: Severe Combined Immunodeficiency National Institutes of Health Statistics and Research Early Treatment Benefits Infants with Severe Combined Immunodeficiency National Institute of Allergy and Infectious Diseases Gene Risk Factors for Age-Related Brain Disorders May Affect Immune System Function National Institute on Aging LAD-1 Peridontitis: Rolling on…and on National Institute of Dental and Craniofacial Research Genetics Genetics Home Reference: 22q11.2 deletion syndrome National Library of Medicine Genetics Home Reference: activated PI3K-delta syndrome National Library of Medicine Genetics Home Reference: adenosine deaminase deficiency National Library of Medicine Genetics Home Reference: anhidrotic ectodermal dysplasia with immune deficiency National Library of Medicine Genetics Home Reference: autoimmune lymphoproliferative syndrome National Library of Medicine Genetics Home Reference: autosomal dominant hyper-IgE syndrome National Library of Medicine Genetics Home Reference: autosomal recessive hyper-IgE syndrome National Library of Medicine Genetics Home Reference: Chediak-Higashi syndrome National Library of Medicine Genetics Home Reference: chronic granulomatous disease National Library of Medicine Genetics Home Reference: common variable immune deficiency National Library of Medicine Genetics Home Reference: complement component 2 deficiency National Library of Medicine Genetics Home Reference: complement component 8 deficiency National Library of Medicine Genetics Home Reference: complement factor I deficiency National Library of Medicine Genetics Home Reference: Erdheim-Chester disease National Library of Medicine Genetics Home Reference: familial hemophagocytic lymphohistiocytosis National Library of Medicine Genetics Home Reference: Griscelli syndrome National Library of Medicine Genetics Home Reference: hepatic veno-occlusive disease with immunodeficiency National Library of Medicine Genetics Home Reference: immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome National Library of Medicine Genetics Home Reference: IRAK-4 deficiency National Library of Medicine Genetics Home Reference: Langerhans cell histiocytosis National Library of Medicine Genetics Home Reference: leukocyte adhesion deficiency type 1 National Library of Medicine Genetics Home Reference: mannose-binding lectin deficiency National Library of Medicine Genetics Home Reference: multiple sclerosis National Library of Medicine Genetics Home Reference: MyD88 deficiency National Library of Medicine Genetics Home Reference: purine nucleoside phosphorylase deficiency National Library of Medicine Genetics Home Reference: Schimke immuno-osseous dysplasia National Library of Medicine Genetics Home Reference: spondyloenchondrodysplasia with immune dysregulation National Library of Medicine Genetics Home Reference: T-cell immunodeficiency, congenital alopecia, and nail dystrophy National Library of Medicine Genetics Home Reference: trichohepatoenteric syndrome National Library of Medicine Genetics Home Reference: Wiskott-Aldrich syndrome National Library of Medicine Genetics Home Reference: X-linked agammaglobulinemia National Library of Medicine Genetics Home Reference: X-linked hyper IgM syndrome National Library of Medicine Genetics Home Reference: X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection, and neoplasia National Library of Medicine Genetics Home Reference: X-linked lymphoproliferative disease National Library of Medicine Genetics Home Reference: X-linked severe combined immunodeficiency National Library of Medicine Genetics Home Reference: ZAP70-related severe combined immunodeficiency National Library of Medicine Learning about Severe Combined Immunodeficiency (SCID) National Human Genome Research Institute Living With How to Keep an Infusion Log: Intravenous Immune Globulin (IVIG) Immune Deficiency Foundation Teenagers Immune System Nemours Foundation Start Here Immune System National Institute of Allergy and Infectious Diseases Health Check Tools Immune System Quiz Nemours Foundation Seniors Immune System: Can Your Immune System Still Defend You As You Age? National Institute on Aging Children Our Immune System Immune Deficiency Foundation Repeated Infections in Children American Academy of Family Physicians Severe Combined Immunodeficiency (For Parents) Nemours Foundation Weakened Immune Systems American Academy of Pediatrics What Is a Pediatric Allergist / Immunologist? American Academy of Pediatrics Games Play the Immune System Defender Game Nobel Foundation Journal Articles Immune system Immune system diseases Latest News Gene Therapy May Offer Hope for ‘Bubble Boy’ Disease HealthDay