- Acute Flaccid Myelitis
- Alzheimer’s Disease
- Arteriovenous Malformations
- Attention Deficit Hyperactivity Disorder
- Back Pain
- Brain Aneurysm
- Brain Tumors
- Carpal Tunnel Syndrome
- Childhood Brain Tumors
- Delirium
- Dementia
- Hemorrhagic Stroke
- Ischemic Stroke
- Memory
- Meningitis
- Mild Cognitive Impairment
- Movement Disorders
- Multiple Sclerosis
- Neuroblastoma
- Neuromuscular Disorders
- Parkinson’s Disease
- Polio and Post-Polio Syndrome
- Speech and Language Problems in Children
- Stroke
- Transient Ischemic Attack
- Tremor
- Walking Problems
- West Nile Virus
- A1C
- Blood Glucose
- Diabetes
- Diabetes and Pregnancy
- Diabetes Complications
- Diabetes in Children and Teens
- Diabetes Medicines
- Diabetes Type 1
- Diabetes Type 2
- Diabetic Diet
- Diabetic Eye Problems
- Diabetic Foot
- Diabetic Heart Disease
- Diabetic Kidney Problems
- Diabetic Nerve Problems
- How to Prevent Diabetes
- Hyperglycemia
- Metabolic Syndrome
- Prediabetes
- Abortion
- Breast Cancer
- Breast Diseases
- Breast Reconstruction
- Breastfeeding
- Cervical Cancer
- Cervical Cancer Screening
- Cesarean Delivery
- Childbirth
- Ectopic Pregnancy
- Endometriosis
- Female Infertility
- Health Problems in Pregnancy
- High Blood Pressure in Pregnancy
- HIV and Pregnancy
- Hormone Replacement Therapy
- HPV
- Hysterectomy
- Infections and Pregnancy
- Mammography
- Mastectomy
- Menopause
- Menstruation
- Miscarriage
- Ovarian Cancer
- Ovarian Cysts
- Ovarian Disorders
- Pelvic Floor Disorders
- Pelvic Inflammatory Disease
- Pelvic Pain
- Period Pain
- Polycystic Ovary Syndrome
- Pregnancy
- Pregnancy and Drug Use
- Pregnancy and Opioids
- Premenstrual Syndrome
- Prenatal Care
- Prenatal Testing
- Primary Ovarian Insufficiency
- Sexual Problems in Women
- Stillbirth
- Teenage Pregnancy
- Trichomoniasis
- Tubal Ligation
- Uterine Cancer
- Uterine Diseases
- Uterine Fibroids
- Vaginal Bleeding
- Vaginal Cancer
- Vaginal Diseases
- Vaginitis
- Vulvar Cancer
- Vulvar Disorders
- Yeast Infections
- Alcohol
- Calcium
- Child Nutrition
- Cholesterol
- Cholesterol Levels: What You Need to Know
- Cholesterol Medicines
- DASH Eating Plan
- Eating Disorders
- Food Allergy
- HDL: The “Good” Cholesterol
- High Cholesterol in Children and Teens
- How to Lower Cholesterol
- How to Lower Cholesterol with Diet
- Infant and Newborn Nutrition
- LDL: The “Bad” Cholesterol
- Malabsorption Syndromes
- Nutrition for Older Adults
- Pregnancy and Nutrition
- Toddler Nutrition
- Triglycerides
- VLDL Cholesterol
- Alpha-1 Antitrypsin Deficiency
- Ataxia Telangiectasia
- Brain Malformations
- Cerebral Palsy
- Charcot-Marie-Tooth Disease
- Chiari Malformation
- Cleft Lip and Palate
- Color Blindness
- Congenital Heart Defects
- Craniofacial Abnormalities
- Cystic Fibrosis
- Ehlers-Danlos Syndrome
- Fetal Alcohol Spectrum Disorders
- Friedreich Ataxia
- Genetic Counseling
- Hemophilia
- Huntington’s Disease
- Hydrocephalus
- Muscular Dystrophy
- Neural Tube Defects
- Neurofibromatosis
- Newborn Screening
- Osteogenesis Imperfecta
- Prader-Willi Syndrome
- Pregnancy and Medicines
- Rett Syndrome
- Sickle Cell Disease
- Spina Bifida
- Spinal Muscular Atrophy
- Tay-Sachs Disease
- Tourette Syndrome
- Tuberous Sclerosis
- Usher Syndrome
- Acute Lymphocytic Leukemia
- Allergy
- Animal Bites
- Ankylosing Spondylitis
- Aplastic Anemia
- Asthma
- Asthma in Children
- Childhood Leukemia
- Childhood Vaccines
- Chronic Lymphocytic Leukemia
- COVID-19 Vaccines
- Cryptosporidiosis
- Eosinophilic Disorders
- Eosinophilic Esophagitis
- Giant Cell Arteritis
- Hay Fever
- HIV
- HIV and Infections
- HIV in Women
- Hodgkin Lymphoma
- Infectious Diseases
- Infectious Mononucleosis
- Juvenile Arthritis
- Kawasaki Disease
- Lymphedema
- Lymphoma
- Multiple Myeloma
- Pemphigus
- Pneumocystis Infections
- Rheumatoid Arthritis
- Scleroderma
- Sjogren’s Syndrome
- Tonsillitis
- Vaccines
- Viral Infections
- Adhesions
- Ankle Injuries and Disorders
- Arm Injuries and Disorders
- Back Injuries
- Brachial Plexus Injuries
- Burns
- Chest Injuries and Disorders
- Concussion
- CPR
- Dislocated Shoulder
- Dislocations
- Elbow Injuries and Disorders
- Eye Injuries
- Facial Injuries and Disorders
- Finger Injuries and Disorders
- Foot Injuries and Disorders
- Fractures
- Hand Injuries and Disorders
- Heel Injuries and Disorders
- Hip Injuries and Disorders
- Inhalation Injuries
- Insect Bites and Stings
- Jaw Injuries and Disorders
- Knee Injuries and Disorders
- Leg Injuries and Disorders
- Mosquito Bites
- Neck Injuries and Disorders
- Rotator Cuff Injuries
- Shoulder Injuries and Disorders
- Spinal Cord Injuries
- Sprains and Strains
- Tick Bites
- Toe Injuries and Disorders
- Traumatic Brain Injury
- Wrist Injuries and Disorders
- Acute Bronchitis
- Bird Flu
- Chronic Bronchitis
- COPD
- COVID-19 (Coronavirus Disease 2019)
- Croup
- E-Cigarettes
- Fistulas
- Flu
- Granulomatosis with Polyangiitis
- H1N1 Flu (Swine Flu)
- Legionnaires’ Disease
- Lung Cancer
- Mesothelioma
- Pneumonia
- Pulmonary Hypertension
- Respiratory Syncytial Virus Infections
- Sleep Apnea
- Smoking
- Tuberculosis
- Whooping Cough
- Anatomy
- Assisted Reproductive Technology
- Birth Control
- Chlamydia Infections
- Circumcision
- Erectile Dysfunction
- Genital Herpes
- Genital Warts
- Gonorrhea
- Herpes Simplex
- Infertility
- Male Infertility
- Penis Disorders
- Prostate Cancer
- Prostate Cancer Screening
- Prostate Diseases
- Reproductive Hazards
- Sexual Health
- Sexual Problems in Men
- Sexually Transmitted Diseases
- Syphilis
- Testicular Cancer
- Testicular Disorders
- Vasectomy
- Abdominal Pain
- Bad Breath
- Bleeding
- Breathing Problems
- Bruises
- Chest Pain
- Choking
- Chronic Pain
- Constipation
- Cough
- Diarrhea
- Dizziness and Vertigo
- Edema
- Fainting
- Fever
- Frostbite
- Gas
- Gastrointestinal Bleeding
- Headache
- Heartburn
- Heat Illness
- Hives
- Hypothermia
- Indigestion
- Itching
- Jaundice
- Nausea and Vomiting
- Pain
- Rare Diseases
- Raynaud’s Disease
- Sciatica
- Speech and Communication Disorders
- Stuttering
Metabolic Disorders
Summary
Metabolism is the process your body uses to get or make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Chemicals in your digestive system break the food parts down into sugars and acids, your body’s fuel. Your body can use this fuel right away, or it can store the energy in your body tissues, such as your liver, muscles, and body fat.
A metabolic disorder occurs when abnormal chemical reactions in your body disrupt this process. When this happens, you might have too much of some substances or too little of other ones that you need to stay healthy. There are different groups of disorders. Some affect the breakdown of amino acids, carbohydrates, or lipids. Another group, mitochondrial diseases, affects the parts of the cells that produce the energy.
You can develop a metabolic disorder when some organs, such as your liver or pancreas, become diseased or do not function normally. Diabetes is an example.
National Institute of Diabetes and Digestive and Kidney Diseases
Genetics
- Acatalasemia: MedlinePlus Genetics National Library of Medicine
- ALG1-congenital disorder of glycosylation: MedlinePlus Genetics National Library of Medicine
- ALG12-congenital disorder of glycosylation: MedlinePlus Genetics National Library of Medicine
- ALG6-congenital disorder of glycosylation: MedlinePlus Genetics National Library of Medicine
- Aspartylglucosaminuria: MedlinePlus Genetics National Library of Medicine
- Beta-ureidopropionase deficiency: MedlinePlus Genetics National Library of Medicine
- Biotinidase deficiency: MedlinePlus Genetics National Library of Medicine
- Carbonic anhydrase VA deficiency: MedlinePlus Genetics National Library of Medicine
- Chylomicron retention disease: MedlinePlus Genetics National Library of Medicine
- Citrullinemia: MedlinePlus Genetics National Library of Medicine
- Congenital hyperinsulinism: MedlinePlus Genetics National Library of Medicine
- Dihydropyrimidinase deficiency: MedlinePlus Genetics National Library of Medicine
- Dihydropyrimidine dehydrogenase deficiency: MedlinePlus Genetics National Library of Medicine
- Fumarase deficiency: MedlinePlus Genetics National Library of Medicine
- Glutathione synthetase deficiency: MedlinePlus Genetics National Library of Medicine
- GM1 gangliosidosis: MedlinePlus Genetics National Library of Medicine
- Hypophosphatasia: MedlinePlus Genetics National Library of Medicine
- Molybdenum cofactor deficiency: MedlinePlus Genetics National Library of Medicine
- Mucolipidosis II alpha/beta: MedlinePlus Genetics National Library of Medicine
- Mucolipidosis III alpha/beta: MedlinePlus Genetics National Library of Medicine
- Mucolipidosis III gamma: MedlinePlus Genetics National Library of Medicine
- Multiple sulfatase deficiency: MedlinePlus Genetics National Library of Medicine
- N-acetylglutamate synthase deficiency: MedlinePlus Genetics National Library of Medicine
- NGLY1-congenital disorder of deglycosylation: MedlinePlus Genetics National Library of Medicine
- Ornithine transcarbamylase deficiency: MedlinePlus Genetics National Library of Medicine
- Phosphoribosylpyrophosphate synthetase superactivity: MedlinePlus Genetics National Library of Medicine
- PMM2-congenital disorder of glycosylation: MedlinePlus Genetics National Library of Medicine
- Pseudocholinesterase deficiency: MedlinePlus Genetics National Library of Medicine
- Short stature, hyperextensibility, hernia, ocular depression, Rieger anomaly, and teething delay: MedlinePlus Genetics National Library of Medicine
- Sialic acid storage disease: MedlinePlus Genetics National Library of Medicine
- Sialidosis: MedlinePlus Genetics National Library of Medicine
- Sialuria: MedlinePlus Genetics National Library of Medicine
- SLC35A2-congenital disorder of glycosylation: MedlinePlus Genetics National Library of Medicine
- Trichothiodystrophy: MedlinePlus Genetics National Library of Medicine
- Trimethylaminuria: MedlinePlus Genetics National Library of Medicine
Patient Handouts
- Acidosis Medical Encyclopedia
- Alkalosis Medical Encyclopedia
- Lactic acid test Medical Encyclopedia
- Metabolic acidosis Medical Encyclopedia
- Metabolic neuropathies Medical Encyclopedia
- Pseudohypoparathyroidism Medical Encyclopedia
Encyclopedia
- Blood gases Medical Encyclopedia
- Crigler-Najjar syndrome Medical Encyclopedia
- Dementia due to metabolic causes Medical Encyclopedia
- Hereditary urea cycle abnormality Medical Encyclopedia
- Homocystinuria Medical Encyclopedia
- Inborn errors of metabolism Medical Encyclopedia
- Lesch-Nyhan syndrome Medical Encyclopedia
- Transient familial hyperbilirubinemia Medical Encyclopedia
- Urine odor Medical Encyclopedia
Clinical Trials
- ClinicalTrials.gov: Metabolic Diseases National Institutes of Health
- ClinicalTrials.gov: Mucolipidoses National Institutes of Health
Diagnosis and Tests
- Comprehensive Metabolic Panel (CMP) National Library of Medicine
- Lactic Acid Test National Library of Medicine
- Newborn Screening: MedlinePlus Health Topic National Library of Medicine
Find an Expert
- Genetic and Rare Diseases Information Center Genetic and Rare Diseases Information Center
- National Institute of Diabetes and Digestive and Kidney Diseases National Institute of Diabetes and Digestive and Kidney Diseases
Specifics
- Learning about Trimethylaminuria National Human Genome Research Institute
- Lesch-Nyhan Syndrome National Institute of Neurological Disorders and Stroke
- What Is a Urea Cycle Disorder? National Urea Cycle Disorders Foundation
Start Here
- Metabolism Nemours Foundation