Diabetes Insipidus Summary Diabetes insipidus (DI) causes frequent urination. You become extremely thirsty, so you drink. Then you urinate. This cycle can keep you from sleeping or even make you wet the bed. Your body produces lots of urine that is almost all water. DI is different from diabetes mellitus (DM), which involves insulin problems and high blood sugar. The symptoms can be similar. However, DI is related to how your kidneys handle fluids. It’s much less common than DM. Urine and blood tests can show which one you have. Usually, DI is caused by a problem with your pituitary gland or your kidneys. Treatment depends on the cause of the problem. Medicines can often help. NIH: National Institute of Diabetes and Digestive and Kidney Diseases National Institute of Diabetes and Digestive and Kidney Diseases Diagnosis and Tests ADH (Antidiuretic Hormone) Test American Association for Clinical Chemistry Osmolality Test American Association for Clinical Chemistry Sodium Test American Association for Clinical Chemistry Urinalysis American Association for Clinical Chemistry Encyclopedia Antidiuretic hormone blood test Thirst – excessive Urine 24-hour volume Urine concentration test Clinical Trials ClinicalTrials.gov: Diabetes Insipidus National Institutes of Health Start Here Diabetes Insipidus National Institute of Diabetes and Digestive and Kidney Diseases Diabetes Insipidus Endocrine Society Array Diabetes insipidus Diabetes insipidus – central Diabetes insipidus – nephrogenic Patient Handouts Diabetes Insipidus National Institute of Diabetes and Digestive and Kidney Diseases Children Diabetes Insipidus, Central (For Parents) Nemours Foundation Genetics Genetics Home Reference: Erdheim-Chester disease National Library of Medicine Genetics Home Reference: nephrogenic diabetes insipidus National Library of Medicine Genetics Home Reference: neurohypophyseal diabetes insipidus National Library of Medicine Genetics Home Reference: nonsyndromic holoprosencephaly National Library of Medicine Genetics Home Reference: Wolfram syndrome National Library of Medicine Find an Expert National Institute of Diabetes and Digestive and Kidney Diseases National Institute of Diabetes and Digestive and Kidney Diseases Journal Articles Diabetes Insipidus