Herpes Simplex Summary Herpes is an infection that is caused by a herpes simplex virus (HSV). Oral herpes causes cold sores around the mouth or face. Genital herpes affects the genitals, buttocks or anal area. Genital herpes is a sexually transmitted disease (STD). It affects the genitals, buttocks or anal area. Other herpes infections can affect the eyes, skin, or other parts of the body. The virus can be dangerous in newborn babies or in people with weak immune systems. There are two types of HSV: HSV type 1 most commonly causes cold sores. It can also cause genital herpes. HSV type 2 is the usual cause of genital herpes, but it also can infect the mouth. HSV spreads through direct contact. Some people have no symptoms. Others get sores near the area where the virus has entered the body. They turn into blisters, become itchy and painful, and then heal. Most people have outbreaks several times a year. Over time, you get them less often. Medicines to help your body fight the virus can help lessen symptoms and decrease outbreaks. National Institute of Allergy and Infectious Diseases Clinical Trials ClinicalTrials.gov: Herpes Simplex National Institutes of Health Encyclopedia Erythema multiforme Pregnancy and herpes Array Esophagitis – infectious Herpes viral culture of lesion Serum herpes simplex antibodies Diagnosis and Tests Herpes American Association for Clinical Chemistry Specifics Herpes Keratitis American Academy of Ophthalmology Start Here Herpes Simplex American Academy of Dermatology Children Herpes Simplex Virus (Cold Sores) American Academy of Pediatrics Herpes Simplex Virus (HSV) Logical Images Herpes Simplex Virus (HSV) in Infants and Babies Logical Images Images Herpetic Whitlow Logical Images Sacral Herpes Logical Images Find an Expert National Institute of Allergy and Infectious Diseases National Institute of Allergy and Infectious Diseases Journal Articles Herpes Simplex