Creutzfeldt-Jakob Disease Summary Creutzfeldt-Jakob disease (CJD) is a rare, degenerative brain disorder. Symptoms usually start around age 60. Memory problems, behavior changes, vision problems, and poor muscle coordination progress quickly to dementia, coma, and death. Most patients die within a year. The three main categories of CJD are Sporadic CJD, which occurs for no known reason Hereditary CJD, which runs in families Acquired CJD, which occurs from contact with infected tissue, usually during a medical procedure Cattle can get a disease related to CJD called bovine spongiform encephalopathy (BSE) or “mad cow disease.” There is concern that people can get a variant of CJD from eating beef from an infected animal, but there is no direct proof to support this. NIH: National Institute of Neurological Disorders and Stroke National Institute of Neurological Disorders and Stroke Statistics and Research Bovine Spongiform Encephalopathy (BSE), or Mad Cow Disease Centers for Disease Control and Prevention Prion Diseases National Institute of Allergy and Infectious Diseases Related Issues Bovine Spongiform Encephalopathy: Production and Inspection Department of Agriculture, Food Safety and Inspection Service Creutzfeldt-Jakob Disease Fact Sheet for Healthcare Workers and Morticians National Institute of Neurological Disorders and Stroke Information for People Treated with Human Growth Hormone (Comprehensive Report) National Institute of Diabetes and Digestive and Kidney Diseases Information for People Treated with Human Growth Hormone (Summary) National Institute of Diabetes and Digestive and Kidney Diseases Kuru National Institute of Neurological Disorders and Stroke Risk for Travelers Centers for Disease Control and Prevention Find an Expert Centers for Disease Control and Prevention Centers for Disease Control and Prevention Food and Drug Administration Food and Drug Administration National Institute of Neurological Disorders and Stroke National Institute of Neurological Disorders and Stroke Clinical Trials ClinicalTrials.gov: Creutzfeldt-Jakob Syndrome National Institutes of Health ClinicalTrials.gov: Prion Diseases National Institutes of Health Start Here Creutzfeldt-Jakob Disease Alzheimer’s Association Creutzfeldt-Jakob Disease Mayo Foundation for Medical Education and Research Creutzfeldt-Jakob Disease National Institute of Neurological Disorders and Stroke Creutzfeldt-Jakob Disease National Institute of Neurological Disorders and Stroke Relationship with BSE (Mad Cow Disease) Centers for Disease Control and Prevention Transmissible Spongiform Encephalopathies (Prion Diseases) National Institute of Neurological Disorders and Stroke Array Creutzfeldt-Jakob disease Diagnosis and Tests Diagnosing Sporadic Creutzfeldt-Jakob Disease: Accuracy of CSF 14-3-3 Protein Test of the Spinal Fluid American Academy of Neurology Specifics Frequently Asked Questions on BSE (Bovine Spongiform Encephalopathy or Mad Cow Disease) Department of Agriculture Variant Creutzfeldt-Jakob Disease (vCJD) Centers for Disease Control and Prevention Genetics Genetics Home Reference: prion disease National Library of Medicine Encyclopedia Kuru Teenagers Mad Cow Disease Nemours Foundation Children Mad Cow Disease (For Parents) Nemours Foundation What’s Mad Cow Disease? Nemours Foundation Journal Articles Creutzfeldt-Jakob disease Mad cow disease