Chronic Myeloid Leukemia Also called: CML, Chronic granulocytic leukemia, Chronic myelogenous leukemia Summary Leukemia is cancer of the white blood cells. White blood cells help your body fight infection. Your blood cells form in your bone marrow. In leukemia, the bone marrow produces abnormal white blood cells. These cells crowd out the healthy blood cells, making it hard for blood to do its work. In chronic myeloid leukemia (CML), there are too many granulocytes, a type of white blood cell. Most people with CML have a gene mutation (change) called the Philadelphia chromosome. Sometimes CML does not cause any symptoms. If you have symptoms, they may include: Fatigue Weight loss Night sweats Fever Pain or a feeling of fullness below the ribs on the left side Tests that examine the blood and bone marrow diagnose CML. Treatments include chemotherapy, stem cell transplants, infusion of donated white blood cells following stem cell transplants, surgery to remove the spleen, and biologic and targeted therapies. Biologic therapy boosts your body’s own ability to fight cancer. Targeted therapy uses substances that attack cancer cells without harming normal cells. NIH: National Cancer Institute National Cancer Institute Array After chemotherapy – discharge Bone marrow transplant Bone marrow transplant – discharge Chronic myelogenous leukemia (CML) Find an Expert American Cancer Society American Cancer Society Find a Cancer Doctor American Society of Clinical Oncology Leukemia & Lymphoma Society Leukemia & Lymphoma Society National Cancer Institute National Cancer Institute NCI Designated Cancer Centers National Cancer Institute Specifics Atypical Chronic Myelogenous Leukemia National Cancer Institute What Should You Ask Your Doctor about Chronic Myeloid Leukemia? American Cancer Society Diagnosis and Tests BCR-ABL1: Test American Association for Clinical Chemistry How Is Chronic Myeloid Leukemia Diagnosed? American Cancer Society Lab and Imaging Tests Leukemia & Lymphoma Society MedlinePlus: Blood Count Tests National Library of Medicine Stages of Chronic Myelogenous Leukemia National Cancer Institute What Are Bone Marrow Tests? National Heart, Lung, and Blood Institute Treatments and Therapies Blood Transfusion Leukemia & Lymphoma Society Immunotherapy Leukemia & Lymphoma Society Integrative Medicine and Complementary and Alternative Therapies Leukemia & Lymphoma Society MedlinePlus: Bone Marrow Transplantation National Library of Medicine Treating Chronic Myeloid Leukemia by Phase American Cancer Society Treatment Option Overview (Chronic Myelogenous Leukemia) National Cancer Institute Treatment Options for Chronic Myelogenous Leukemia National Cancer Institute Understanding Side Effects of Drug Therapy Leukemia & Lymphoma Society Encyclopedia Bone marrow biopsy Bone-marrow transplant – slideshow Cryoglobulins Fibrinopeptide A blood test Statistics and Research Cancer Statistics: Chronic Myeloid Leukemia National Cancer Institute What’s New in Chronic Myeloid Leukemia Research and Treatment? American Cancer Society NIH MedlinePlus Magazine Cancer Strikes Out!/Definitions/ Glossary/ Common Types Start Here Chronic Myelogenous Leukemia Mayo Foundation for Medical Education and Research Chronic Myelogenous Leukemia (CML) National Marrow Donor Program Chronic Myeloid Leukemia Leukemia & Lymphoma Society General Information about Chronic Myelogenous Leukemia National Cancer Institute What Is Chronic Myeloid Leukemia? American Cancer Society What You Need to Know about Leukemia National Cancer Institute Clinical Trials ClinicalTrials.gov: Leukemia, Myelogenous, Chronic, BCR-ABL Positive National Institutes of Health ClinicalTrials.gov: Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative National Institutes of Health Types of Treatment: Clinical Trials Leukemia & Lymphoma Society Genetics Do We Know What Causes Chronic Myeloid Leukemia? American Cancer Society Seniors Leukemia National Cancer Institute Journal Articles Chronic Myeloid Leukemia Patient Handouts Understanding Chemotherapy National Cancer Institute Prevention and Risk Factors What Are the Risk Factors for Chronic Myeloid Leukemia? American Cancer Society
